Auto-Immune & Inflammatory Conditions Affecting the Upper Airway
Auto-Immune & Inflammatory Conditions Affecting the Upper Airway
The upper airway is what connects the back of the throat down to the individual lungs. This is composed of the larynx (voice box), trachea (windpipe), and bronchi (branches of windpipe connecting to the lungs). This area of the body can be affected by a variety of auto-immune and inflammatory conditions.
What conditions affect the upper airway?
- Granulomatosis with polyangiitis (GPA)/Wegener’s granulomatosis – a form of vasculitis that causes inflammation of the blood vessels; this typically affects the sinuses, lungs and kidneys, but can impact other tissues and organs. The majority of patients with GPA will develop a manifestation in the ear, nose, trachea or bronchi.
- Eosinophilic granulomatosis with polyangiitis/Churg-Strauss syndrome – also a form of vasculitis characterized by inflammation of the blood vessels. This condition most often affects the sinuses, heart, lungs, intestines and nerves. It could also affect the kidneys, muscles or joints. It can occur in patients with a history of allergies or asthma.
- Sarcoidosis – an inflammatory disease which can affect multiple organs in the body. It is most commonly seen in the lungs and lymph nodes. When it affects the airways, it most often affects the larynx (voice box).
- Amyloidosis – a condition where excessive proteins are deposited into the body’s tissues causing masses. Amyloidosis can occur sporadically or can be associated with underlying conditions such as multiple myeloma.
- Relapsing Polychondritis – a rare condition where recurrent episodes of inflammation affect the cartilages in the body. When this affects the cartilages of the upper airway, it can cause collapse or narrowing of the airway.
- IgG4–related disease – a rare condition where inflammatory cells can infiltrate tissues and cause scarring due to over-expression of a certain immune system protein, IgG4.
- Inflammatory Bowel Disease – such as Ulcerative Colitis or Crohn’s disease
Appointment Information
Please call 734-936-8051 to schedule an appointment with one of our Otolaryngology providers.
What are the symptoms of these conditions?
The symptoms of auto-immune and inflammatory conditions of the airways vary depending on the disease and areas affected. Common symptoms include:
- Difficulties with breathing, such as shortness of breath, wheezing, or stridor (high-pitched breathing on inspiration)
- Chronic cough
- Hoarseness
- Recurring respiratory tract infections
- Shortness of breath
- Bleeding from the airway (hemoptysis)
- Sinusitis
- Difficulty Swallowing
How are upper airway conditions diagnosed?
At the Complex Airway Disorders Program, your evaluation is customized to your condition. Your evaluation may include:
- A complete history of your breathing problem
- A physical examination of your head, neck, and chest
- Evaluation your breathing ability through pulmonary function testing (PFTs)
- Examination of your throat, voice box, and airway through endoscopy in the clinic or operating room
- Imaging of your airways via X-rays or computed tomography (CT) scans. This may include Dynamic 3D Chest CT-scans, a non-invasive procedure performed with the patient inhaling and exhaling to examine how the airways change with breathing.
How are upper airway conditions treated?
Non-Surgical Treatment
In many cases, inflammatory and autoimmune airway disease improves with treatment of the underlying condition. Frequently, consultation with a rheumatologist, immunologist, pulmonologist, or hematologist is necessary to discuss treatment options and prevent recurrence of the airway condition.
Surgical Treatment
For patients who do not benefit from systemic treatment, we offer surgical procedures to improve symptoms with narrowing or collapse of their airways due to the autoimmune condition. These include:
- Endoscopic Dilation — While examining your airway through the mouth while you are asleep, a balloon or dilator is used to widen (stretch) the airway. Often times, steroid is injected into the area or a medication called mitomycin is applied to prevent recurrence of scar.
- Laser Treatment – While examining your airway through the mouth while you are asleep, a laser is use to vaporize and cut the scar in your airway to increase the space to breathe through.
- Endoscopic Resection — Also called the Maddern procedure, in this procedure, your surgeon uses a laser to strip all the scar from the narrow area. The airway is then relined with a graft of different tissue. A temporary silicone stent is applied while the graft integrates with your airway.
- Tracheobronchial Stenting – While examining your airway through the mouth while you are asleep, the area of narrowing is propped open with an expandable stent made of metal or silicone inserted into the airway through a bronchoscope.
- Open Airway Reconstruction – Via an incision through the neck, the area of scarring or narrowing is cut away (resected), and the two remaining ends of the airway sewn back together resulting in an unobstructed airway. This is called either a tracheal resection or cricotracheal resection, depending on the areas that are removed. Laryngotracheal reconstruction is when a cartilage graft is also used to expand your airway.
- Tracheostomy or T-tube – An incision is made in to the airway, and a tube is inserted into the airway to either bypass or expand the area of narrowing and allow normal breathing
Locations
-
Otolaryngology Clinic | Brighton Center for Specialty Care 7500 Challis Rd
Entrance 1, Level 2
Brighton, MI 48116-9416Get Directions -
Otolaryngology Clinic | Taubman Center 1500 E Medical Center Dr
Floor 1 Reception A
Ann Arbor, MI 48109-5312Get Directions -
Vocal Health Center | Taubman Center 1500 E Medical Center Dr
Floor 1 Reception A
Ann Arbor, MI 48109-5312Get Directions
Doctors
Norman Dertad Hogikyan, MD, F.A.C.S.
Professor
Otolaryngology
Robbi Ann Kupfer, MD
Clinical Associate Professor
Otolaryngology
Robert James Morrison, MD
Clinical Associate Professor
Otolaryngology
News & Stories
After near-fatal car crash, singer regains voice at U-M Vocal Health Center
Pollen exposure linked to worse quality of life for chronic sinus infection sufferers
AI supports home-based balance training
Human ability to focus on specific sounds not found to originate in auditory nerve, brainstem
Addressing body-image distress in head and neck cancer patients