Henry Lauris Paulson, MD
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About
Henry L. Paulson, M.D., Ph.D., is the Lucile Groff Professor of Neurology for Alzheimer's Disease and Related Disorders in the Department of Neurology at the University of Michigan. Dr. Paulson joined the U-M faculty in 2007, and he currently directs the Michigan Alzheimer’s Disease Center (MADC) and co-direct the U-M Protein Folding Diseases Initiative.
Dr. Paulson received his medical degree and doctorate in Cell Biology from Yale University in 1990. He then completed a neurology residency and neurogenetics/movement disorders fellowships at the University of Pennsylvania. In 1997, he joined the Neurology faculty at the University of Iowa, where he remained until 2007.
Dr. Paulson's research and clinical interests concern the causes and treatment of age-related neurodegenerative diseases, with an emphasis on polyglutamine diseases, Alzheimer's disease and frontotemporal dementia. In 1997, his lab described abnormal protein aggregates in the polyglutamine diseases, which now are recognized as a pathological hallmark in this important class of inherited diseases. Using test tube, cell-based and animal models, he has contributed to advances in the understanding of various neurodegenerative diseases. His lab also has helped pioneer the use of gene silencing methods as potential therapy for the many neurological disorders caused by toxic mutant genes.
Nationally, Dr. Paulson has directed popular courses at the American Academy of Neurology meetings, serves on the scientific advisory boards of numerous disease-related national organizations, and is past Chair of the Board of Scientific Counselors at the National Institute for Neurological Disorders and Stroke at the National Institutes of Health.
Among his awards, Dr. Paulson is an Ellison Medical Foundation New Scholar in Aging, a semifinalist for the W.M. Keck Foundation Young Scholars in Medical Research, and a recipient of the Paul Beeson Physician Faculty Scholar in Aging Award from the American Federation for Aging Research.
Areas of Practice
Neurology, Neurodegenerative diseases including Alzheimer’s disease and related dementias and hereditary ataxias.
Expertise
Locations
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Geriatric Neurology Clinic | East Ann Arbor Health & Geriatrics Center 4260 Plymouth Rd
Level 1
Ann Arbor, MI 48109-2700Get Directions
Insurance Accepted
University of Michigan Health participates with most health insurance plans.
Education & Training
Medical School or Training
Residency
Fellowships
Board Certifications
Research Overview
Neurodegenerative diseases caused by abnormal proteins; Spinocerebellar Ataxia type 3; RNA interference as potential therapy including studies of polyglutamine diseases and Alzheimer's disease; Protein quality control in normal brain function and in neurodegenerative diseases
Links
Patient Ratings & Comments
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Patient Ratings
97 Patient Ratings
Patient Comments
February 28, 2026 - "Dr. Paulson is a highly intelligent, excellent listener...usually using follow-up questions to further understand what I am feeling/saying. Explains compilated statements/concepts in a way I can understand."
December 20, 2025 - "Dr Paulson explained everything very well and took my questions seriously and gave easy to understand answers. He made sure that I felt comfortable in talking and asking questions."
November 15, 2025 - "Dr. Paulson is a professionally frank physician. A quality that is deeply appreciated. He is empathetic but it is rooted in practical and concrete suggestions"
October 21, 2025 - "Dr. Paulson was very thorough and patient. He discussed my problem in detail and gave clear explanations and suggestions. He checked me and took the necessary tests in the room. He then ordered the [...]. I now have most of the test results and look forward to talking to him on phone when he calls."
October 19, 2025 - "Dr. Paulson is very patient as well as very highly qualified."
September 1, 2025 - "Dr. Paulson went out of his way to schedule this appointment with me and then spent an extraordinary amount of time with me, both in discussion and examination. Although the concern was not directly within his present specialty, he was clearly knowledgeable of the issue. He made the diagnosis and initiated the treatment plan with medication. He then personally ensured a follow-up appointment [...] I am very grateful to him for starting me on the path to better health."
August 17, 2025 - "Dr. Paulson was very up-to-date on his knowledge of my concerns and I just thank God that I was sent to him. Can't wait for more visits. A big thank you"
May 21, 2025 - "Dr. Paulson has wisdom and grace"
May 2, 2025 - "I was very impressed with Dr. Paulson."
April 15, 2025 - "[...] My faith in Dr. Paulson and [...] is extremely high. He really knows his stuff. [...]"
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