If you are a patient looking to receive care for upper tract urothelial cancer, please call 734–647–8902 to make an appointment.

Healthcare professionals may contact M-Line: 800-962-3555.

Symptoms may include:

• Blood in the urine (visible or microscopic)
• Flank or abdominal pain
• Unexplained weight loss or fatigue

Some patients are diagnosed during evaluation for blood in the urine without other symptoms.

Diagnosis begins with a review of symptoms, medical history, and physical examination. Testing may include:

• Urine testing and cytology to detect cancer cells
• Imaging studies such as CT scan or MRI to evaluate the kidneys and ureters
• Endoscopic evaluation of the urinary tract to directly visualize tumors

Biopsy may be performed to confirm the diagnosis and determine tumor grade, which helpsguide treatment decisions.

Treatment depends on tumor size, grade, location, kidney function, and patient health. Care is individualized and may include the following approaches:

Endoscopic Management

For selected patients with small, low-grade tumors, cancer may be treated using minimally invasive endoscopic techniques. These procedures are performed through the urinary tract and allow removal or destruction of tumors while preserving the kidney. Endoscopic management requires careful follow-up due to the risk of recurrence.

Surgery (Nephroureterectomy)

For larger, higher-grade, or invasive tumors, surgery to remove the kidney and ureter—called a nephroureterectomy—is often recommended. This approach provides the best chance for cure in patients with more aggressive disease. Surgery may be performed using open or minimally invasive techniques, depending on the individual case.

Additional Treatments

Some patients may require chemotherapy before or after surgery, depending on tumor characteristics and whether the cancer has spread. Treatment plans are developed by a multidisciplinary team to optimize cancer control while preserving quality of life.