Sibutramine
Drug Information
Caution: The manufacturer of this drug is removing this product from the US market. If you currently have a prescription for this medicine you should immediately speak to your doctor before making a change to your treatment plan.
Sibutramine is used for the management of obesity, including weight loss and maintenance of weight loss, and should be used in association with a reduced calorie diet.
Common brand names:
MeridiaSummary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
none
Reduce Side Effects
none
Support Medicine
none
Reduces Effectiveness
none
Potential Negative Interaction
- 5-HTP
The amino acids L-tryptophan and 5-hydroxytryptophan (5-HTP) are occasionally used to treat mental depression. Taking sibutramine with L-tryptophan or 5-HTP might result in a rare, but serious group of symptoms known as “serotonin syndrome.” Symptoms associated with serotonin syndrome may include confusion, anxiety, muscle weakness, incoordination, and vomiting. Therefore, individuals taking sibutramine should avoid supplementing with L-tryptophan and 5-HTP.
One side effect of sibutramine is high blood pressure. Ephedra, an herb that until 2004 was used in cold remedies and herbal weight loss products, contains ephedrine, which can also increase blood pressure. Though no studies have investigated whether taking sibutramine together with ephedra might produce an adverse interaction, currently available evidence suggests that this combination should be used with caution.
- L-Tryptophan
The amino acids L-tryptophan and 5-hydroxytryptophan (5-HTP) are occasionally used to treat mental depression. Taking sibutramine with L-tryptophan or 5-HTP might result in a rare, but serious group of symptoms known as “serotonin syndrome.” Symptoms associated with serotonin syndrome may include confusion, anxiety, muscle weakness, incoordination, and vomiting. Therefore, individuals taking sibutramine should avoid supplementing with L-tryptophan and 5-HTP.
Explanation Required
none
Last Review: 03-18-2015
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