Salsalate
Drug Information
Salsalate is used to treat rheumatoid arthritis and osteoarthritis and is in a class of medications known as non-steroidal anti-inflammatory drugs (NSAIDs).
Common brand names:
Amigesic, Disalcid, Salflex, SalsitabSummary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
- Folic Acid
Salsalate and aspirin produce anti-inflammatory effects after they are converted in the body to salicylic acid. Studies have shown that aspirin can reduce the amount of folic acid in the blood, though it is not known whether this change is significant. Controlled studies are needed to determine whether people taking salsalate are at risk for folic acid deficiency.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence. - Potassium
Salsalate and aspirin are rapidly converted in the body to salicylic acid. Taking large amounts of aspirin can result in lower than normal blood levels of potassium, though it is not known whether this change is significant. Controlled studies are needed to determine whether people taking salsalate are at risk for potassium deficiency.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence. - Vitamin C
Salsalate and aspirin are rapidly converted in the body to salicylic acid. Controlled studies show that taking aspirin increases the elimination of vitamin C from the body and lowers blood levels. Further controlled research is needed to determine whether salsalate specifically reduces vitamin C levels and whether people taking the drug are at risk for vitamin C deficiency.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Reduce Side Effects
none
Support Medicine
none
Reduces Effectiveness
none
Potential Negative Interaction
- White Willow
Willow bark contains salicin, which is related to aspirin. Salsalate, salicin, and aspirin produce anti-inflammatory effects after they have been converted to salicylic acid in the body. Taking aspirin at the same time as other salicylate drugs can result in adverse effects, such as ringing in the ears, dizziness, headache, confusion, and diarrhea. Though there are no studies specifically investigating an interaction between willow bark and salsalate, people taking salsalate should probably avoid using the herb until more information is available.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Explanation Required
none
Last Review: 03-18-2015
![Aisle7 Logo](https://content.healthwise.net/resources/14.0/en-us/media/medical/cam/a7_a7logocpyrt105.gif)
Copyright © 2024 TraceGains, Inc. All rights reserved.
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. The TraceGains knowledgebase does not contain every possible interaction.
Learn more about TraceGains, the company.
The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.
Topic Contents
This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.