Drug Information
Common brand names:
Amigesic, Disalcid, Salflex, SalsitabSummary of Interactions with Vitamins, Herbs, & Foods
Types of interactions:BeneficialAdverseCheck
Replenish Depleted Nutrients
- Folic Acid
Salsalate and aspirin produce anti-inflammatory effects after they are converted in the body to salicylic acid. Studies have shown that aspirin can reduce the amount of folic acid in the blood, though it is not known whether this change is significant. Controlled studies are needed to determine whether people taking salsalate are at risk for folic acid deficiency.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
- Potassium
Salsalate and aspirin are rapidly converted in the body to salicylic acid. Taking large amounts of aspirin can result in lower than normal blood levels of potassium, though it is not known whether this change is significant. Controlled studies are needed to determine whether people taking salsalate are at risk for potassium deficiency.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
- Vitamin C
Salsalate and aspirin are rapidly converted in the body to salicylic acid. Controlled studies show that taking aspirin increases the elimination of vitamin C from the body and lowers blood levels. Further controlled research is needed to determine whether salsalate specifically reduces vitamin C levels and whether people taking the drug are at risk for vitamin C deficiency.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Potential Negative Interaction
- White Willow
Willow bark contains salicin, which is related to aspirin. Salsalate, salicin, and aspirin produce anti-inflammatory effects after they have been converted to salicylic acid in the body. Taking aspirin at the same time as other salicylate drugs can result in adverse effects, such as ringing in the ears, dizziness, headache, confusion, and diarrhea. Though there are no studies specifically investigating an interaction between willow bark and salsalate, people taking salsalate should probably avoid using the herb until more information is available.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
