Drug Information
Lansoprazole is a “proton pump inhibitor” drug that blocks production of stomach acid. Lansoprazole is used to treat diseases in which stomach acid causes damage, including stomach and duodenal ulcers, esophagitis, and Zollinger-Ellison syndrome.
Common brand names:
Prevacid, Prevacid IV, Prevacid SoluTabSummary of Interactions with Vitamins, Herbs, & Foods
Types of interactions:BeneficialAdverseCheck
Replenish Depleted Nutrients
- Calcium
In a study of elderly women, administration of omeprazole decreased the absorption of calcium, presumably because the drug decreased the stomach's production of hydrochloric acid, which is necessary for calcium absorption. The form of calcium used in the study to test calcium absorption was calcium carbonate. Drugs that reduce stomach acid secretion may not inhibit other forms of calcium, such as calcium citrate.
- Folic Acid
Folic acid is needed by the body to utilize vitamin B12. Antacids, including lansoprazole, inhibit folic acid absorption. People taking antacids are advised to supplement with folic acid.
- Vitamin C
Treatment of healthy volunteers with omeprazole for four weeks resulted in a 12.3% decrease in blood levels of vitamin C.
- Magnesium
In a case report, a man developed severe magnesium deficiency after long-term treatment with a proton pump inhibitor (pantoprazole or lansoprazole). Severe magnesium deficiency as a result of the use of proton pump inhibitors appears to be rare among people who have no other risk factors for magnesium deficiency. However, in a study of hospitalized patients, the prevalence of low serum magnesium levels was significantly greater among users of proton pump inhibitors than among nonusers (23% vs. 11%). People taking proton pump inhibitors (PPIs) should ask their doctor whether to take a magnesium supplement or whether to have their magnesium levels monitored.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Support Medicine
- Cranberry
Omeprazole was shown to reduce protein-bound vitamin B12 absorption and cranberry (Vaccinium macrocarpon) juice was shown to increase protein-bound vitamin B12 absorption in eight people treated with omeprazole (a drug closely related to lansoprazole). While this effect has not been studied with lansoprazole, people taking lansoprazole may choose to drink cranberry juice or other acidic liquids with vitamin B12-containing foods. Unlike vitamin B12 found in food, vitamin B12 found in supplements is not bound to peptides (pieces of protein). The absorption of B12 supplements therefore does not require acid and is unlikely to be improved by drinking cranberry juice.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Potential Negative Interaction
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
