Drug Information
Common brand names:
PlendilSummary of Interactions with Vitamins, Herbs, & Foods
Types of interactions:BeneficialAdverseCheck
Replenish Depleted Nutrients
- Calcium
A study of felodipine indicated that the drug caused increased excretion of calcium. Whether this effect could lead to increased bone loss is unknown, but some health practitioners may recommend calcium supplementation to individuals taking felodipine. Although the effectiveness of some calcium channel blockers may be reduced with calcium supplementation, this effect has not been observed in people taking felodipine.
- Magnesium
Increased magnesium excretion has been observed in studies of individuals taking felodipine. Therefore, some physicians may recommend magnesium supplementation to their patients taking felodipine.
- Potassium
Felodipine can lead to increased excretion of potassium. A potassium deficiency may result if potassium intake is not sufficient. People taking felodipine should eat a high-potassium diet and be checked regularly for low blood potassium by a doctor.
Potential Negative Interaction
Regular consumption of grapefruit juice can increase the quantity of felodipine in the blood by reducing the breakdown of the drug. The inhibitory effect of grapefruit juice lasts up to 24 hours after ingestion and can increase blood levels nearly three times the expected amount. In order to prevent side effects of the drug, individuals who are taking felodipine should avoid grapefruit and its juice.
Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice. The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with felodipine in the same way that grapefruit juice does.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
- Quercetin
Quercetin is a flavonoid found in grapefruit juice, tea, onions, and other foods; it is also available as a nutritional supplement. Quercetin has been shown in test tube studies to inhibit enzymes responsible for breaking down felodipine into an inactive form. This interaction may result in increased blood levels of felodipine that could lead to unwanted side effects. Until more is known about this interaction, patients taking felodipine should avoid supplementing with quercetin.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Explanation Required
- Pleurisy Root
As pleurisy root and other plants in the Aesclepius genus contain cardiac glycosides, it is best to avoid use of pleurisy root with heart medications such as calcium channel blockers.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
