Pioglitazone-Glimepiride
Drug Information
Common brand names:
DuetactSummary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
none
Reduce Side Effects
none
Support Medicine
- Magnesium
Supplementing magnesium may enhance the blood-sugar-lowering effects of sulfonylurea drugs. Though no current studies have investigated whether glimepiride increases the risk of developing hypoglycemia, individuals should closely monitor their blood glucose while taking glimepiride together with magnesium supplements.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Reduces Effectiveness
none
Potential Negative Interaction
- Ginkgo
In a preliminary trial, administration of Ginkgo biloba extract (120 mg per day) for three months to patients with type 2 diabetes who were taking oral anti-diabetes medication resulted in a significant worsening of glucose tolerance. Ginkgo did not impair glucose tolerance in individuals whose diabetes was controlled by diet. Individuals taking oral anti-diabetes medication should consult a doctor before taking Ginkgo biloba.
- Vitamin B3 (Niacin)
Vitamin B3 can raise blood sugar levels, which makes diabetes difficult to control. Use of niacin along with glimepiride may increase requirements for the drug. On the other hand, individuals who stop taking niacin while on glimepiride should monitor their blood for lower-than-usual glucose levels.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Explanation Required
none
Last Review: 03-24-2015
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