Quinidine Gluconate
Drug Information
Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
none
Reduce Side Effects
- Beta-Carotene
Some people taking quinidine develop sensitivity to ultraviolet radiation from the sun. In a preliminary study, three people with quinidine-induced skin inflammation were able to tolerate intense sun exposure without recurrence of the rash after supplementing with 90–180 mg of beta-carotene each day. Further research is needed to confirm that people taking quinidine can prevent side effects by supplementing with beta-carotene.
- Magnesium
Two individuals taking sotalol developed a side effect of the drug (a heart arrhythmia known as torsades de pointes) which was effectively treated with intravenous magnesium. Additional research is needed to determine whether people taking sotalol might be able to prevent this side effect by taking supplemental magnesium.
Support Medicine
none
Reduces Effectiveness
none
Potential Negative Interaction
Drinking grapefruit juice together with quinidine increases the amount of time that the drug remains in the body, which might increase the likelihood of side effects and toxicity. Therefore, based on currently available information, people taking quinidine should avoid drinking grapefruit juice or eating grapefruit.
Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice. The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with quinidine in the same way that grapefruit juice does.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Explanation Required
One controlled study showed that people consuming a high-salt diet had dramatically lower quinidine blood levels compared with people on a low-salt diet. Problems might occur when people switch from a high-salt diet to a low-salt diet and vice versa. Therefore, people taking quinidine should notify their health practitioner before changing their salt intake.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.One controlled study showed that people consuming a high-salt diet had dramatically lower quinidine blood levels compared with people on a low-salt diet. Problems might occur when people switch from a high-salt diet to a low-salt diet and vice versa. Therefore, people taking quinidine should notify their health practitioner before changing their salt intake.
The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Last Review: 03-24-2015
![Aisle7 Logo](https://content.healthwise.net/resources/14.0/en-us/media/medical/cam/a7_a7logocpyrt105.gif)
Copyright © 2024 TraceGains, Inc. All rights reserved.
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article. The TraceGains knowledgebase does not contain every possible interaction.
Learn more about TraceGains, the company.
The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2024.
Topic Contents
This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.