Instructions
Drink the medicine.
This medicine may be taken with or without food.
This medicine will work best if you take it at about the same time every day.
Store in refrigerator until first use, then at controlled room temperature.
Keep the medicine away from heat and light.
Store in original bottle, tightly closed and upright.
Do not store above 77 degrees F (25 degrees C).
Remove unopened bottle from refrigerator 30-60 minutes before first use.
Do not freeze the medicine.
Shake the bottle well before using the medicine.
If stored at room temperature, discard any unused medicine after 60 days.
It is important that you keep taking each dose of this medicine on time even if you are feeling well.
If you forget to take a dose on time, take it as soon as you remember. If it is almost time for the next dose, do not take the missed dose. Return to your normal schedule. Do not take 2 doses at one time.
Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.
Tell your doctor if symptoms do not get better or if they get worse.
Check product labels carefully and avoid foods, beverages and supplements that contain aspartame, phenylalanine or tyrosine.
The foods you eat can change how well this medicine works. Tell your doctor about the types of food you normally eat. Ask your doctor for a list of foods that can affect this medicine. Do not significantly change the foods you normally eat while on this medicine.
If you have been on this medicine for more than a week, do not suddenly stop taking it without your doctor's approval. It could worsen your symptoms.
Keep all appointments for medical exams and tests while on this medicine.
Do not take the medicine more than twice during 24 hours.
Brand Name(s): Orfadin
Generic Name: Nitisinone
Cautions
You should have an eye exam before starting this medicine.
Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.
Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.
This medicine can damage the eyes and cause severe vision loss. Stop taking this medicine and call your doctor immediately if you notice any changes in vision. These changes may be blurred vision, double vision, vision loss, light sensitivity, or eye pain.
It is very important that you carefully measure the amount of medicine you take. Your healthcare provider or pharmacist should show you the correct way to measure this medicine.
Do not use the medication any more than instructed.
Call the doctor if there are any signs of confusion or unusual changes in behavior.
This medicine may reduce your body's ability to fight infections. Avoid contact with people with colds, flu or other infections. Contact your doctor if you develop fever, cough, sore throat, or chills.
Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding.
Do not share this medicine with anyone who has not been prescribed this medicine.
Side Effects
The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.
- diarrhea
- headaches
- stomach upset or abdominal pain
Call your doctor or get medical help right away if you notice any of these more serious side effects:
- bleeding or bruising
- delays in development such as holding head up, rolling over and crawling
- eye pain, redness, or itching
- fever or chills
- sores or blisters on hands or feet
- signs of liver damage (such as yellowing of eye or skin, dark urine, or unusual tiredness)
- dry skin
- sore throat
- sudden change or loss of vision
A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.
Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.
IMPORTANT NOTE: This document tells you briefly how to take your medicine, but it does not tell you all there is to know about it. Your doctor or pharmacist may give you other documents about your medicine. Please talk to them if you have any questions. Always follow their advice.
There is a more complete description of this medicine available in English. Scan this code on your smartphone or tablet or use the web address below. You can also ask your pharmacist for a printout. If you have any questions, please ask your pharmacist.
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More information about NITISINONE - ORAL
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Selected from data included with permission and copyright by First DataBank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
Conditions of Use: The information in this database is intended to supplement, not substitute for the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The display and use of this drug information is subject to express Terms of Use.
