Instructions
This medicine should be given by a trained health care provider.
If you miss a dose, contact your doctor for instructions.
Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.
Tell your doctor if symptoms do not get better or if they get worse.
Talk to your doctor before taking other medicines, including aspirins and ibuprofen containing products. Speak to your doctor about which medicines are safe to use while you are on this medicine.
Keep all appointments for medical exams and tests while on this medicine.
Brand Name(s): Xiaflex
Generic Name: Collagenase Clostridium Histolyticum
Cautions
This medicine may cause serious bleeding problems in patients taking blood thinner medications. Follow your doctor's instructions carefully to monitor your blood lab tests if you are on blood thinners.
Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.
Rarely, this medicine may cause serious injury at the site of injection. Call your doctor right away if you notice any pain, swelling, blisters, sores, lumps under the skin, or scabbing at the injection site.
Few patients may experience tendon problems. This is more common in patients older than 60. If you notice pain, swelling, or difficulty moving your joints, tell your doctor. This can happen even after stopping the medicine for a few months.
Contact your doctor if you develop any signs of a new infection such as fever, cough, sore throat, or chills.
Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding.
Some patients have serious side effects from this medicine. Ask your pharmacist to show you the information from the Food and Drug Administration (FDA) and discuss it with you.
Side Effects
Call your doctor or get medical help right away if you notice any of these more serious side effects:
- back pain
- unusual bruising or discoloration on skin
- dizziness
- fainting
- numbness or tingling in hands and feet
- pain, redness, swelling near injection
- new or worsening movement problems
- red, burning, or itchy skin
- problems with sexual functions or desire
- red, peeling or blistering skin
- difficulty or discomfort urinating
- blood in urine
A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.
Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.
IMPORTANT NOTE: This document tells you briefly how to take your medicine, but it does not tell you all there is to know about it. Your doctor or pharmacist may give you other documents about your medicine. Please talk to them if you have any questions. Always follow their advice.
There is a more complete description of this medicine available in English. Scan this code on your smartphone or tablet or use the web address below. You can also ask your pharmacist for a printout. If you have any questions, please ask your pharmacist.
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More information about COLLAGENASE CLOSTRIDIUM HISTOLYTICUM - INJECTION
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Selected from data included with permission and copyright by First DataBank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
Conditions of Use: The information in this database is intended to supplement, not substitute for the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The display and use of this drug information is subject to express Terms of Use.
