cabotegravir

What is the most important information I should know about cabotegravir?

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

What is cabotegravir?

Cabotegravir is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body. HIV is the virus that can cause acquired immunodeficiency syndrome (AIDS).

Cabotegravir tablet is used together with another antiviral called rilpivirine for treatment of HIV in people 12 years and older weighing at least 77 pounds (35 kg) to replace their current HIV medicines.

Cabotegravir is also used in HIV negative patients to lower the chance of getting HIV infection in people 12 years and older weighing at least 77 pounds (35 kg). You must be HIV negative to start and keep using cabotegravir to lower the chance of getting HIV infection.

Cabotegravir and rilpivirine are given as a daily "lead-in dose" to help determine that you can safely use a combination form of these medicines given as an injection.

Cabotegravir and rilpivirine may also be given short-term in place of the injectable combination if you plan to miss an injection by more than 7 days.

Cabotegravir and rilpivirine is for use in adults who have already used other antiviral HIV medications that have controlled their viral load. These medicines are not a cure for HIV or AIDS.

Cabotegravir may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using cabotegravir?

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with cabotegravir. Your doctor may change your treatment plan if you also use:

• certain antibiotics --rifabutin, rifampin, rifapentine; or
• seizure medicine --carbamazepine, oxcarbazepine, phenobarbital, phenytoin.

Tell your doctor if you have ever had:

• a skin rash or an allergic reaction after using medicine that contains cabotegravir;
• liver disease; or
• mental illness.

Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether cabotegravir will harm an unborn baby. However, HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of cabotegravir on the baby.

How should I use cabotegravir?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Cabotegravir and rilpivirine tablet is usually given once per day starting at least 28 days before you switch to the injectable combination.

Cabotegravir injection is injected into the muscle of your buttock once every month for the first 2 months, then once every 2 months.

On the last day you take cabotegravir and rilpivirine tablets, you will receive your first injectable dose of these medicines.

If you miss or plan to miss an injection by more than 7 days, call your healthcare provider to discuss your treatment options.

You must remain under the care of a doctor while using cabotegravir and rilpivirine in tablet or injection form. Stay on schedule to get the most benefit. Missing doses can increase your risk of HIV that is resistant to medication.

You will need frequent medical tests. Cabotegravir and rilpivirine can have long lasting effects on your body (up to 12 months after your last dose). You may still need medical tests for a short time after you stop using this medicine.

What happens if I miss a dose?

Take the medicine as soon as you can. Do not take two doses at one time.

Try not to miss any doses, and be sure you have enough tablets for required doses.

What happens if I overdose?

What should I avoid while using cabotegravir?

Cabotegravir and rilpivirine is a complete treatment. Do not use other HIV medications unless your doctor tells you to.

Using this medicine may not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Ask your doctor how to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe.

What are the possible side effects of cabotegravir?

• extreme tiredness, fever, not feeling well;
• muscle or joint pain;
• blisters or sores in or around your mouth;
• red or puffy eyes; or
• swelling in your face or mouth, trouble breathing.

• unusual changes in mood such as feeling sad, hopeless, anxious, or restless;
• suicidal thoughts or actions; or
• liver problems --loss of appetite, nausea, vomiting, stomach pain (upper right side), dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

• nausea;
• abnormal dreams;
• feeling anxious;
• headache; or
• sleep problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect cabotegravir?

Some antacids can make cabotegravir much less effective when taken at the same time. If you take an antacid, take it at least 2 hours before or 4 hours after you take cabotegravir.

Other drugs may affect cabotegravir, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about cabotegravir.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 3.01. Revision date: 5/23/2022.