ripretinib

What is the most important information I should know about ripretinib?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What is ripretinib?

Ripretinib is used in adults to treat tumors of the stomach and intestines.

Ripretinib is for use in adults who have already been treated with at least 3 other cancer medicines.

Ripretinib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking ripretinib?

Tell your doctor if you have ever had:

• a skin problem called palmar-plantar erythrodysesthesia syndrome;
• high blood pressure;
• heart problems; or
• if you have recently had surgery or plan to have surgery.

Using ripretinib may increase your risk of developing skin cancer. Your skin may need to be checked while you are using this medicine. Ask your doctor about skin symptoms to watch for.

You may need to have a negative pregnancy test before starting this treatment.

Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 week after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using ripretinib.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because ripretinib can harm an unborn baby.

How should I take ripretinib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take the medicine at the same time each day, with or without food.

If you vomit shortly after taking ripretinib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.

Your blood pressure will need to be checked often. Your heart function may also need to be checked.

If you need surgery, tell your surgeon you currently use this medicine. You may need to stop for a short time.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Do not change your dose or stop taking ripretinib without your doctor's advice.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if you are more than 8 hours late for the dose. Do not take two doses at one time.

What happens if I overdose?

What should I avoid while taking ripretinib?

What are the possible side effects of ripretinib?

• severe stomach pain, nausea, or vomiting;
• severe headache, blurred vision, pounding in your neck or ears;
• pain, blisters, bleeding, or severe rash in the palms of your hands or the soles of your feet;
• heart problems --tiredness, feeling short of breath, swollen veins in the sides of your neck, swelling in your stomach or lower legs;
• low red blood cells (anemia) --pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
• skin changes --a new wart, a skin sore or red bump that bleeds or does not heal, or any change in the size or color of a mole.

Common side effects may include:

• nausea, vomiting, stomach pain, loss of appetite;
• diarrhea, constipation;
• tiredness;
• muscle pain; or
• thinning hair, hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ripretinib?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your other medicines, especially blood pressure medicine.

Other drugs may affect ripretinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about ripretinib.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 3.01. Revision date: 9/23/2022.