glasdegib

What is the most important information I should know about glasdegib?

What is glasdegib?

Glasdegib is used in adults in combination with cytarabine to treat acute myeloid leukemia. This combination is for use in adults who are 75 years or older, or who cannot receive chemotherapy due to other medical conditions.

Glasdegib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking glasdegib?

Tell your doctor if you have ever had:

• heart problems;
• long QT syndrome (in you or a family member);
• an electrolyte imbalance (such as low blood levels of potassium or magnesium);
• muscle pain or muscle spasms;
• kidney disease; or
• liver disease.

You will need to take a pregnancy test within 7 days of starting treatment with glasdegib.

Men using glasdegib should use condoms during treatment, even after a vasectomy and for at least 30 days after treatment ends.

It may be harder for you to get a woman pregnant while you are using this medicine.

How should I take glasdegib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Glasdegib is given in a 28-day treatment cycle, usually for a total of 6 cycles. Glasdegib is taken by mouth. Your doctor will determine how long to treat you with this medicine.

Take the medicine once a day at the same time each day, with or without food.

If you vomit shortly after taking glasdegib, do not take another dose. Take your next dose as scheduled.

Your heart function may need to be checked using an electrocardiogram or ECG (sometimes called an EKG).

You will need frequent medical tests and your cancer treatments may be delayed based on the results.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not use two doses within 12 hours.

What happens if I overdose?

Overdose symptoms may include tiredness, nausea, vomiting, dizziness, feeling like you might pass out, thirst, and little or no urination.

What should I avoid while taking glasdegib?

Do not donate semen while you are taking glasdegib, and for at least 30 days after your last dose.

What are the possible side effects of glasdegib?

• irregular or fast heartbeats, shortness of breath, and sudden dizziness (like you might pass out);
• easy bruising, unusual bleeding, purple or red spots under your skin;
• any new or worsening muscle pain or muscle spasms; or
• low blood cell counts --fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• bleeding;
• fever, low blood cell counts;
• changes in your sense of taste;
• pain or sores in mouth or throat;
• loss of appetite, constipation, nausea;
• rash;
• muscle pain;
• swelling in your arms or legs;
• feeling tired; or
• trouble breathing.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect glasdegib?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Other drugs may affect glasdegib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Where can I get more information?

Your doctor or pharmacist can provide more information about glasdegib.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 3.01. Revision date: 5/2/2023.