talazoparib

What is the most important information I should know about talazoparib?

Using talazoparib may increase your risk of developing bone marrow problems or leukemia.

Your blood will be tested before and during treatment and your cancer treatments may be delayed based on the results.

What is talazoparib?

Talazoparib is used in adults to treat certain type of breast cancer that has spread to other parts of the body.

Your doctor will make sure you have the correct tumor type to be treated with talazoparib.

Talazoparib may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking talazoparib?

Tell your doctor if you have ever had:

• kidney disease.

Using talazoparib may increase your risk of developing bone marrow problems or leukemia. Ask your doctor about your individual risk.

• If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 7 months after your last dose.
• If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.
• Tell your doctor right away if a pregnancy occurs.

It may be harder for you to get a woman pregnant while you are using this medicine. You should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

How should I take talazoparib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take talazoparib with or without food.

If you vomit shortly after taking talazoparib, do not take another dose. Take your next dose as scheduled.

Talazoparib is usually given until your body no longer responds to the medication.

You may get infections or bleed more easily. Your blood will be tested before and during treatment and your cancer treatments may be delayed based on the results.

Do not change your dose or stop using this medicine without your doctor's advice.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

What should I avoid while taking talazoparib?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of talazoparib?

• blood in your urine or stools;
• easy bruising, unusual bleeding, purple or red spots under your skin;
• weight loss;
• frequent infections;
• low red blood cells (anemia) --pale skin, weakness, tiredness, feeling light-headed or short of breath, cold hands and feet; or
• low white blood cell counts --fever, mouth sores, skin sores, sore throat, cough.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• low blood cell counts;
• nausea, vomiting, diarrhea, loss if appetite;
• hair loss;
• headache; or
• feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect talazoparib?

Tell your doctor about all your other medicines, especially:

• amiodarone;
• carvedilol;
• clarithromycin;
• itraconazole; or
• verapamil.

This list is not complete. Other drugs may affect talazoparib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about talazoparib.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 4.01. Revision date: 5/11/2023.