dapagliflozin

What is the most important information I should know about dapagliflozin?

Tell your doctor if you are sick with vomiting or diarrhea, or if you eat or drink less than usual.

What is dapagliflozin?

Dapagliflozin is used with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus (not for type 1 diabetes).

Dapagliflozin is also used to lower the risk of needing to be in a hospital for heart failure in adults with type 2 diabetes who also have heart disease.

Dapagliflozin is also used in adults to lower the risk of dying or needing to be in a hospital for heart failure when your heart cannot pump blood properly.

Dapagliflozin is also used to reduce the risk of end-stage kidney disease and hospitalization or death from heart problems in adults who also have kidney problems caused by type 2 diabetes.

Dapagliflozin may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking dapagliflozin?

• severe kidney disease (or if you are on dialysis); or
• diabetic ketoacidosis (call your doctor for treatment).

Tell your doctor if you have ever had:

• polycystic kidney disease;
• liver disease;
• bladder infections or other urination problems;
• problems with your pancreas, including surgery;
• alcoholism, or if you currently drink large amounts of alcohol; or
• if you are on a low salt diet.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy.

How should I take dapagliflozin?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take dapagliflozin with or without food.

Your blood sugar will need to be checked often, and you may also need to test the level of ketones in your urine. Dapagliflozin can cause life-threatening ketoacidosis (too much acid in the blood). Even if your blood sugar is normal, contact your doctor if a urine test shows that you have high ketones in the urine.

Blood sugar can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using dapagliflozin.

Your treatment may also include diet, exercise, weight control, and special medical care.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

What should I avoid while taking dapagliflozin?

What are the possible side effects of dapagliflozin?

• dehydration --dizziness, confusion, feeling very thirsty, less urination;
• kidney problems --little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
• ketoacidosis (too much acid in the blood) --nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing; or
• signs of a bladder infection --pain or burning when you urinate, increased urination, blood in your urine, fever, pain in your pelvis or back.

Some side effects may be more likely to occur in older adults.

Common side effects may include:

• genital yeast infection;
• urinating more than usual; or
• sore throat and runny or stuffy nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect dapagliflozin?

Other drugs may increase or decrease the effects of dapagliflozin on lowering your blood sugar. Tell your doctor about all your current medicines and any you start or stop using, especially:

• insulin or other oral diabetes medicines;
• a diuretic or "water pill"; or
• lithium.

This list is not complete. Other drugs may affect dapagliflozin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your doctor or pharmacist can provide more information about dapagliflozin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 10.02. Revision date: 11/13/2022.