lurasidone

What is the most important information I should know about lurasidone?

Some people have thoughts about suicide while taking lurasidone. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

What is lurasidone?

Lurasidone is an antipsychotic medicine that is used to treat schizophrenia in adults and teenagers who are at least 13 years old.

Lurasidone is also used to treat episodes of depression related to bipolar disorder (manic depression) in adults and children who are at least 10 years old.

Lurasidone may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking lurasidone?

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with lurasidone. Your doctor may change your treatment plan if you also use:

• antifungal medicine such as ketoconazole or voriconazole;
• an antibiotic such as clarithromycin or rifampin;
• an antiviral such as ritonavir;
• St. John's wort; or
• seizure medicine such as carbamazepine or phenytoin.

Tell your doctor if you have ever had:

• heart disease or a stroke;
• high or low blood pressure;
• high cholesterol or triglycerides (a type of fat in the blood);
• diabetes or high blood sugar (in you or your family);
• a seizure;
• liver or kidney disease;
• low white blood cell (WBC) counts;
• abnormal hormone function tests (thyroid, pituitary gland);
• breast cancer; or
• suicidal thoughts or actions.

Some people have thoughts about suicide while taking lurasidone. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn. If you get pregnant, tell your doctor right away. Do not stop taking lurasidone without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of lurasidone on the baby.

How should I take lurasidone?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You may need frequent blood tests.

You should not stop using lurasidone suddenly. Stopping suddenly may cause other problems.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

What should I avoid while taking lurasidone?

Grapefruit and grapefruit juice may interact with lurasidone and lead to unwanted side effects. Avoid the use of grapefruit products while taking lurasidone.

What are the possible side effects of lurasidone?

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

High doses or long-term use of lurasidone can cause a serious movement disorder that may not be reversible. The longer you use lurasidone, the more likely you are to develop this disorder, especially if you are a woman or an older adult.

• any new or unusual muscle movements you cannot control;
• a light-headed feeling, like you might pass out;
• a seizure (convulsions);
• (in women) irregular menstrual periods, breast or vaginal changes, nipple discharge;
• (in men) breast swelling, impotence;
• trouble swallowing;
• manic episodes --racing thoughts, increased energy, decreased need for sleep, risk-taking behavior, being agitated or talkative;
• low white blood cell counts --fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing;
• high blood sugar --increased thirst, increased urination, hunger, dry mouth, fruity breath odor; or
• severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects may include:

• drowsiness;
• weight gain;
• tremors, muscle stiffness, slow muscle movement;
• feeling restless or being unable to sit still;
• nausea, vomiting;
• runny nose; or
• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect lurasidone?

Tell your doctor about all your current medicines. Many drugs can affect lurasidone, especially:

• depression or psychotic episodes;
• sleep problems (insomnia);
• high blood pressure or a heart rhythm disorder;
• swelling or inflammation;
• seizures; or
• Parkinson's disease.

This list is not complete and many other drugs may affect lurasidone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about lurasidone.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 8.02. Revision date: 2/5/2020.