cabazitaxel

What is the most important information I should know about cabazitaxel?

Tell your doctor if you have other symptoms of serious side effects: severe stomach pain, blood in your urine or stools, little or no urinating, chest pain, or shortness of breath.

What is cabazitaxel?

Cabazitaxel is used together with prednisone to treat prostate cancer that has spread to other parts of the body (metastatic).

Cabazitaxel is given after other cancer medicines have stopped working.

Cabazitaxel may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving cabazitaxel?

• severe liver problems;
• low white blood cell counts; or
• an allergy to any medicine that contains polysorbate 80.

Tell your doctor if you have ever had:

• radiation treatment;
• liver or kidney disease;
• breathing problems; or
• a severe allergic reaction to any medication.

Use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor at once if a pregnancy occurs during this time.

This medicine may affect fertility (your ability to have children). However, it is important to use birth control to prevent pregnancy because cabazitaxel can harm an unborn baby.

How is cabazitaxel given?

Cabazitaxel is given as an infusion into a vein. A healthcare provider will give you this injection.

Cabazitaxel must be given slowly, and the infusion can take about 1 hour to complete.

Cabazitaxel is usually given once every 3 weeks. You will be given other medications to prevent certain side effects.

Cabazitaxel affects your immune system. You may get infections more easily, even serious or fatal infections, especially if you are 65 or older. Your doctor will need to examine you on a regular basis.

Your doctor may tell you to check your temperature at home throughout your treatment with cabazitaxel.

What happens if I miss a dose?

What happens if I overdose?

Overdose symptoms may include severe vomiting or diarrhea, fever, or worsening flu-like symptoms.

What should I avoid while receiving cabazitaxel?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of cabazitaxel?

• numbness, burning pain, or tingly feeling in your hands or feet;
• sudden chest pain or discomfort, wheezing, dry cough, feeling short of breath;
• stomach pain or tenderness, severe vomiting or diarrhea, ongoing constipation;
• blood in your urine, urinating more often, pain or burning when you urinate;
• low blood cell counts --fever, chills, muscle pain, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath;
• signs of stomach bleeding --bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
• signs of a kidney problem --little or no urinating; painful or difficult urination; swelling in your hands or feet; feeling tired or short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• fever, low blood cell counts;
• numbness or tingling;
• nausea, vomiting, stomach pain, loss of appetite;
• constipation, diarrhea;
• weakness, tired feeling;
• blood in your urine;
• back pain, joint pain;
• cough, shortness of breath;
• altered sense of taste; or
• hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect cabazitaxel?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect cabazitaxel, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about cabazitaxel.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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