sorafenib

What is the most important information I should know about sorafenib?

Sorafenib can also cause severe bleeding. Call your doctor if you have blood in your urine or stools, abnormal vaginal bleeding, severe stomach pain, cough with bloody mucus, or any bleeding that will not stop.

What is sorafenib?

Sorafenib is used to treat liver cancer, thyroid cancer, or kidney cancer.

Sorafenib may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before taking sorafenib?

Tell your doctor if you have ever had:

• heart problems, chest pain, or a heart attack;
• long QT syndrome (in you or a family member);
• high blood pressure;
• an electrolyte imbalance (such as abnormal levels of calcium, magnesium, or potassium in your blood);
• bleeding problems; or
• surgery.

• If you are a woman, do not use sorafenib if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
• If you are a man, use effective birth control if your sex partner is pregnant or is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using sorafenib.

How should I take sorafenib?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Your blood pressure will need to be checked often.

If you need surgery, tell the surgeon or dentist ahead of time that you are using sorafenib. You should stop taking this medicine at least 10 days before having surgery. Follow your doctor's instructions about when to start taking the medicine again.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

What should I avoid while taking sorafenib?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of sorafenib?

• fast or pounding heartbeats, fluttering in your chest;
• shortness of breath, sudden dizziness (like you might pass out);
• easy bruising or bleeding (nosebleeds, bleeding gums);
• heavy menstrual periods or unusual vaginal bleeding;
• pain, redness, swelling, rash, blisters or peeling in the palms of your hands or the soles of your feet;
• fever with nausea, vomiting, or severe stomach pain
• a surgical incision or wound that will not heal;
• liver problems --loss of appetite, stomach pain (upper right side), nausea, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
• signs of bleeding inside your body --pink or brown urine, abnormal vaginal bleeding, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• bleeding;
• feeling tired;
• vomiting, diarrhea, nausea, stomach pain;
• high blood pressure;
• rash; or
• weight loss, thinning hair.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect sorafenib?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect sorafenib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about sorafenib.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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