thyrotropin alfa

What is the most important information I should know about thyrotropin alfa?

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Carefully follow your doctor's instructions about the timing of your medications, scans, and other treatments.

What is thyrotropin alfa?

Thyrotropin alfa is a manmade form of a protein similar to thyroid-stimulating hormone (TSH), which is normally produced by your thyroid. Thyrotropin alfa keeps your TSH levels steady while you undergo thyroid tests or treatments that can reduce TSH and cause symptoms of low thyroid (hypothyroidism).

Thyrotropin alfa is used together with radioactive iodine ablation (a procedure to remove thyroid tissue that was not removed with surgery) in people with thyroid cancer.

Thyrotropin alfa is also used during medical testing to check for certain types of thyroid cancer that has returned after treatment. Thyrotropin alfa may not help your doctor find all signs of cancer, and there is still a chance that some of your cancer could be missed.

Thyrotropin alfa will not treat cancer that has spread to other parts of the body.

Thyrotropin alfa may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving thyrotropin alfa?

To make sure thyrotropin alfa is safe for you, tell your doctor if you have ever had:

• kidney disease (or if you are on dialysis);
• heart disease or history of stroke;
• if you take birth control pills; or
• if you are a woman and you smoke or have migraine headaches.

Tell your doctor if you are pregnant, plan to become pregnant or breastfeeding.

Do not use thyrotropin alfa together with radioactive iodine if your are pregnant or breastfeeding.

How is thyrotropin alfa given?

Thyrotropin alfa is injected into a muscle of the buttock. A healthcare provider will give you this injection.

Thyrotropin alfa is usually given in 2 separate injections 24 hours apart.

You may also be given radioactive iodine to take 24 hours after your last thyrotropin alfa injection. If you need a thyroid scan, the scan should take place 48 hours after you take the radioactive iodine.

You may be given steroid medicine to help keep tumors from growing larger while you are receiving thyrotropin alfa.

Your doctor may want you to receive this medicine in a hospital or clinic setting to quickly treat any serious side effects that occur.

As part of your treatment, you will need frequent blood tests. You may not notice any change in your symptoms, but your blood work will help your doctor determine whether treatment has been effective.

What happens if I miss a dose?

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving thyrotropin alfa?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of thyrotropin alfa?

• throat pain or swelling, trouble breathing;
• severe headache;
• severe nausea or vomiting;
• sudden swelling, pain, numbness, or loss of movement in any part of your body;
• signs of overactive thyroid --unexplained weight loss, increased appetite, changes in bowel habits, fast or pounding heartbeats, sweating, feeling anxious or irritable; or
• signs of a stroke --sudden numbness or weakness (especially on one side of the body), sudden headache, slurred speech, problems with vision or balance.

Common side effects may include:

• nausea, vomiting;
• headache, dizziness; or
• weakness, tiredness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect thyrotropin alfa?

Other drugs may affect thyrotropin alfa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Where can I get more information?

Your doctor or pharmacist can provide more information about thyrotropin alfa.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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