trandolapril and verapamil

What is the most important information I should know about trandolapril and verapamil?

Tell your doctor about all your other medicines. Some drugs should not be used with trandolapril and verapamil.

What is trandolapril and verapamil?

Trandolapril and verapamil is a combination medicine used in adults to treat high blood pressure (hypertension).

Lowering blood pressure may lower your risk of a stroke or heart attack.

Trandolapril and verapamil may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking trandolapril and verapamil?

• "sick sinus syndrome" or "AV block" (unless you have a pacemaker);
• very low blood pressure;
• if your heart cannot pump blood properly;
• an allergy to any other ACE inhibitor, such as benazepril, captopril, fosinopril, enalapril, lisinopril, moexipril, perindopril, quinapril, or ramipril;
• certain heart rhythm disorders (such as 'Afib' or atrial flutter, Wolff-Parkinson-White syndrome or Lown-Ganong-Levine syndrome); or
• if you also use flibanserin (Addyi).

You may not be able to use trandolapril and verapamil if you have:

• severe congestive heart failure.

Do not take trandolapril and verapamil within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not take trandolapril and verapamil with any medication that contains aliskiren (a blood pressure medicine).

Tell your doctor if you have ever had:

• low blood pressure;
• abnormal thickening of the heart muscle;
• congestive heart failure;
• a nerve-muscle disorder such as myasthenia gravis or muscular dystrophy;
• low blood cell counts;
• diabetes;
• cirrhosis or other liver disease; or
• kidney disease (or if you are on dialysis).

You may also need to avoid taking trandolapril and verapamil with aliskiren if you have kidney disease.

How should I take trandolapril and verapamil?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Your blood pressure will need to be checked often, and you may need occasional blood tests.

Tell your doctor if you have a planned surgery.

Keep using this medicine even if you feel well. High blood pressure often has no symptoms.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Overdose symptoms may include slow heart rate, weak pulse, muscle weakness, tingly feeling, seizures, feeling light-headed, or fainting.

What should I avoid while taking trandolapril and verapamil?

Grapefruit may interact with this medicine and cause side effects. Avoid consuming grapefruit products.

Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

What are the possible side effects of trandolapril and verapamil?

• chest pain, fast, slow, or uneven heart rate;
• a light-headed feeling, like you might pass out;
• heart problems --swelling, rapid weight gain, feeling short of breath;
• liver problems --loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• fluid build-up in or around the lungs --pain when you breathe, feeling short of breath while lying down, wheezing, gasping for breath, cough with foamy mucus, cold, clammy skin, anxiety, rapid heartbeats;
• high blood potassium --nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement;
• kidney problems --swelling, urinating less, feeling tired or short of breath; or
• low blood cell counts --fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects may include:

• cough;
• nausea, constipation;
• infections, flu symptoms;
• headache, dizziness;
• swelling;
• low blood pressure; or
• chest pain, back pain, joint pain, pain in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect trandolapril and verapamil?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Trandolapril and verapamil can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, high blood pressure, pain or arthritis (including Advil, Motrin, and Aleve).

If you also take disopyramide, avoid taking it within 48 hours before or 24 hours after you take trandolapril and verapamil.

Many drugs can affect trandolapril and verapamil. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all other medicines you use.

Where can I get more information?

Your doctor or pharmacist can provide more information about trandolapril and verapamil.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 14.01. Revision date: 6/1/2023.