amphetamine

What is the most important information I should know about amphetamine?

Do not use amphetamine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using amphetamine.

What is amphetamine?

Amphetamine is a stimulant medicine that is used to treat attention deficit hyperactivity disorder (ADHD) in children. Some brands of amphetamine are for children 6 years and older. Evekeo can be used in children as young as 3 years old.

Evekeo is also used to treat narcolepsy in adults and children at least 6 years old, or obesity in adults and children at least 12 years old who have not lost weight with diets or other treatments.

Evekeo ODT is used only to treat ADHD in children at least 6 years old.

Amphetamine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking amphetamine?

You may not be able to use amphetamine if you have:

• chest pain or breathing problems caused by heart disease;
• hardening of the arteries;
• moderate to severe high blood pressure;
• overactive thyroid;
• a history of drug abuse; or
• if you are agitated.

• heart problems or a congenital heart defect;
• high blood pressure; or
• a family history of heart disease or sudden death.

Tell your doctor if you or anyone in your family has had:

• depression, mental illness, bipolar disorder, psychosis, or suicidal thoughts or actions;
• problems with drug or alcohol abuse;
• motor tics (muscle twitches) or Tourette's syndrome;
• a thyroid disorder;
• seizures or epilepsy;
• an abnormal brain wave test (electroencephalogram; EEG);
• coronary artery disease (clogged arteries);
• blood circulation problems in the hands or feet; or
• kidney disease.

How should I take amphetamine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Do not use this medicine more often than prescribed.

You may take amphetamine with or without food.

Dynavel XR tablets may be chewed if not able to swallow.

Remove an orally disintegrating tablet from the package with dry hands only when you are ready to use the medicine. Allow the orally disintegrating tablet to dissolve in your mouth without chewing.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the medicine your doctor prescribes.

Your doctor will need to check your progress on a regular basis and may need medical tests to check your heart function. Tell any doctor who treats you that you are using this medicine.

What happens if I miss a dose?

Take the missed dose as soon as you remember, but not late in the day. Skip the missed dose if it is almost evening. Do not take two doses at one time.

What happens if I overdose?

Overdose symptoms may include restlessness, tremor, muscle twitches, rapid breathing, confusion, hostility, hallucinations, heart problems, blood pressure changes, panic, muscle pain or weakness, stomach cramps, vomiting, or diarrhea. These symptoms may be followed by depression and tiredness. Overdose may also lead to seizure or coma.

What should I avoid while taking amphetamine?

Avoid drinking fruit juices such as cranberry juice or taking vitamin C at the same time you take amphetamine. These can make your body absorb less of this medicine.

What are the possible side effects of amphetamine?

• signs of heart problems --chest pain, trouble breathing, feeling like you might pass out;
• signs of psychosis --hallucinations (seeing or hearing things that are not real), new behavior problems, aggression, hostility, paranoia;
• signs of circulation problems --numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes;
• a seizure (convulsions);
• muscle twitches (tics);
• increased blood pressure or heart rate; or
• changes in your vision.

Amphetamine can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Common side effects may include:

• increased heart rate;
• mood changes, anxiety, feeling restless or nervous;
• trouble sleeping;
• dry mouth, stomach pain, nausea, vomiting, diarrhea, constipation;
• loss of appetite, weight loss;
• sexual problems (impotence in males);
• headache, dizziness; or
• itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect amphetamine?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Ask your doctor before using a stomach acid medicine (including Alka-Seltzer or sodium bicarbonate). Some of these medicines can change the way your body absorbs amphetamine and may increase side effects.

Tell your doctor about all your current medicines. Many drugs can affect amphetamine, especially:

• antidepressant including desipramine, protriptyline, paroxetine, fluoxetine;
• lithium or other medicine to treat depression or mental illness;
• blood pressure medicine;
• a blood thinner (warfarin, Coumadin, Jantoven);
• cold or allergy medicine that contains a decongestant;
• opioid (narcotic) medicine; or
• seizure medicine.

This list is not complete and many other drugs may affect amphetamine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your doctor or pharmacist can provide more information about amphetamine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 5.01. Revision date: 5/1/2023.