hydrocortisone (injection)

What is the most important information I should know about hydrocortisone?

Tell your doctor about any illness or infection you have had within the past several weeks.

What is hydrocortisone?

Hydrocortisone is a steroid medicine that is used in the treatment of many different conditions, including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, multiple sclerosis, or lung disorders.

Hydrocortisone is also used to replace steroids in people with adrenal insufficiency (decreased production of natural steroids by the adrenal glands).

Hydrocortisone affects your immune system and is often used to treat certain blood cell disorders such as anemia (low red blood cells) or thrombocytopenia (low platelets).

Hydrocortisone is also used in the treatment of certain cancers such as leukemia, lymphoma, and multiple myeloma.

Hydrocortisone may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using hydrocortisone?

Steroids can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

Tell your doctor if you have ever had:

• heart disease, high blood pressure;
• tuberculosis;
• kidney disease;
• cirrhosis or other liver disease;
• a thyroid disorder;
• low bone mineral density (osteoporosis);
• stomach ulcers, ulcerative colitis, diverticulitis;
• diabetes;
• a colostomy or ileostomy;
• depression or mental illness;
• glaucoma or cataracts;
• herpes infection of the eyes; or
• a muscle disorder such as myasthenia gravis.

Long-term use of steroids may lead to bone loss (osteoporosis), especially if you smoke, if you do not exercise, if you do not get enough vitamin D or calcium in your diet, or if you have a family history of osteoporosis.

How is hydrocortisone given?

Hydrocortisone is injected into a muscle, or given as an infusion into a vein. A healthcare provider will give you this injection.

Hydrocortisone is usually given by injection if you are unable to take the medicine by mouth.

Your doctor will need to check your progress on a regular basis.

Your dose needs may change if you have a serious illness, fever or infection, surgery or a medical emergency. Tell your doctor about any such situation that affects you.

You should not stop using hydrocortisone suddenly. Follow your doctor's instructions about tapering your dose.

What happens if I miss a dose?

What happens if I overdose?

An overdose of hydrocortisone is not expected to produce life threatening symptoms. Long term use of high doses can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while using hydrocortisone?

Do not receive a "live" vaccine while using hydrocortisone. The vaccine may not work as well and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chickenpox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

What are the possible side effects of hydrocortisone?

• blurred vision, tunnel vision, eye pain, or seeing halos around lights;
• muscle weakness, loss of muscle mass;
• new or unusual pain in your joints, bones, or muscles;
• severe headaches, ringing in your ears, pain behind your eyes;
• unusual changes in mood or behavior;
• a seizure;
• hollowing or other skin changes where the injection was given;
• numbness or tingling;
• fluid retention --shortness of breath (even while lying down), swelling, rapid weight gain (especially in your face and midsection);
• new signs of infection --such as fever, chills, cough, trouble breathing, sores in your mouth or on your skin, diarrhea, or burning when you urinate;
• increased adrenal gland hormones --slow wound healing, skin discoloration, thinning skin, increased body hair, tiredness, menstrual changes, sexual changes; or
• decreased adrenal gland hormones --weakness, tiredness, diarrhea, nausea, menstrual changes, skin discoloration, craving salty foods, and feeling light-headed.

Hydrocortisone can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Common side effects may include:

• acne, dry skin;
• increased sweating;
• nausea, bloating;
• increased appetite, weight gain; or
• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hydrocortisone?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can affect hydrocortisone, especially:

• birth control pills or hormone replacement therapy;
• heart medication;
• insulin or oral diabetes medicine;
• medicine to prevent organ transplant rejection;
• medicine to treat an infection;
• seizure medication;
• a blood thinner such as warfarin (Coumadin, Jantoven); or
• aspirin or an NSAID (nonsteroidal anti-inflammatory drug) such as ibuprofen, naproxen, celecoxib, indomethacin, Advil, Aleve, Motrin, and others.

This list is not complete and many other drugs may affect hydrocortisone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your doctor or pharmacist can provide more information about hydrocortisone.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 1.01. Revision date: 1/15/2019.