cisplatin

What is the most important information I should know about cisplatin?

Cisplatin can affect your nervous system, increase your risk of bleeding or infection, or harm your kidneys.

What is cisplatin?

Cisplatin is used together with other cancer drugs to treat bladder cancer, testicular cancer, or ovarian cancer.

Cisplatin may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving cisplatin?

Tell your doctor if you have ever had:

• prior treatment with cisplatin;
• hearing or vision problems;
• bone marrow suppression;
• kidney disease;
• peripheral vascular disease such as Raynaud's syndrome;
• radiation treatment to your brain;
• liver disease; or
• if you have had a severe allergic reaction to similar cancer drugs such as carboplatin or oxaliplatin.

A child treated with cisplatin may need a hearing test before receiving the first dose.

Using cisplatin may increase your risk of developing leukemia. Ask your doctor about your individual risk.

• If you are a woman, do not use cisplatin if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 14 months after your last dose.
• If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 11 months after your last dose.
• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using cisplatin.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because cisplatin can harm an unborn baby.

How is cisplatin given?

Cisplatin is given as an infusion into a vein. A healthcare provider will give you this injection.

Cisplatin is sometimes given for 5 days in a row, or once every 3 to 4 weeks. How often and how many times you receive cisplatin will depend on the type of cancer you have.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when cisplatin is injected.

Cisplatin can increase your risk of bleeding or infection. You will need frequent medical tests. Your cancer treatments may be delayed based on the results.

Cisplatin can harm your kidneys. Drink plenty of fluids each day to keep your kidneys working properly.

What happens if I miss a dose?

What happens if I overdose?

Overdose symptoms may include feeling tired or short of breath, vomiting, pain or numbness, liver or kidney failure, or hearing loss.

What should I avoid while taking cisplatin?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

What are the possible side effects of cisplatin?

You may have a severe allergic reaction within minutes of receiving a cisplatin injection. Your caregivers will quickly treat you if you if this occurs.

• severe or ongoing nausea and vomiting;
• vision problems, pain behind your eyes;
• hearing problems, ringing in your ears;
• pain, redness, swelling, or skin changes where the injection was given;
• bone marrow suppression --dizziness, pale lips or fingernail beds, fast heart rate, getting easily tired or short of breath;
• kidney problems --little or no urination, swelling in your feet or ankles, feeling tired or short of breath;
• low white blood cell counts --fever, mouth sores, skin sores, sore throat, cough, trouble breathing; or
• nervous system problems --decreased muscle reflexes, numbness and tingling or burning pain in your hands or feet.

Nervous system problems may occur up to several weeks after you receive cisplatin, and these effects may not be reversible. Talk to your doctor if you have concerns about this risk.

Nervous system problems may be more likely in older adults.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

• hearing problems;
• kidney problems;
• numbness or tingling;
• nausea, vomiting; or
• bone marrow suppression.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect cisplatin?

Cisplatin can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve).

Other drugs may affect cisplatin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your doctor or pharmacist can provide more information about cisplatin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 8.02. Revision date: 2/26/2021.