Donepezil
Brand Name(s): Aricept®, Aricept® ODT, Namzaric®(as a combination product containing Donepezil, Memantine)
Donepezil is used to treat dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) in people who have Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Donepezil is in a class of medications called cholinesterase inhibitors. It improves mental function (such as memory, attention, the ability to interact with others, speak, think clearly, and perform regular daily activities) by increasing the amount of a certain naturally occurring substance in the brain. Donepezil may improve the ability to think and remember or slow the loss of these abilities in people who have AD. However, donepezil will not cure AD or prevent the loss of mental abilities at some time in the future.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Donepezil comes as a tablet and an orally disintegrating tablet (tablet that dissolves quickly in the mouth) to take by mouth. It is usually taken once a day with or without food, in the evening just before bedtime. Take donepezil at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take donepezil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Donepezil helps control the symptoms of Alzheimer's disease but does not cure it. Continue to take donepezil even if you feel well. Do not stop taking donepezil without talking to your doctor.
Your doctor may start you on a low dose of donepezil and increase your dose after 4 to 6 weeks. Your doctor may increase your dose again 3 or more months later.
Swallow the 23-mg tablet whole; do not split, crush or chew it. Tell your doctor if you are unable to swallow the tablet whole.
To take the orally disintegrating tablet, place the tablet on your tongue and wait for it to dissolve. Drink some water after the tablet dissolves.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Before taking donepezil,
tell your doctor and pharmacist if you are allergic to donepezil, any piperidine medications, any other medications, any of the ingredients in donepezil tablets or orally disintegrating tablets. Ask your doctor or pharmacist if you do not know if a medication that you are allergic to is a piperidine medication. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antihistamines; aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); bethanechol (Duvoid, Urecholine); carbamazepine (Tegretol); dexamethasone (Decadron, Dexone); ipratropium (Atrovent); ketoconazole (Nizoral); medications for glaucoma, irritable bowel disease, motion sickness, myasthenia gravis, Parkinson's disease, ulcers, or urinary problems; phenobarbital (Luminal, Solfoton); phenytoin (Dilantin); quinidine (Quinidex); and rifampin (Rifadin, Rimactane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you weigh less than 120 lb (55 kg) and if you have or have ever had bleeding in your stomach or intestines; an ulcer; irregular, slow, or fast heartbeat, seizures; difficulty urinating; asthma;chronic obstructive pulmonary disease (a group of lung disease including chronic bronchitis or emphysema); or kidney, liver, or heart disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking donepezil, call your doctor.
If you forget to take a dose of donepezil, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. If you do not take donepezil, for 1 week or longer, you should call your doctor before starting to take this medication again.
Donepezil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- nausea
- vomiting
- diarrhea
- loss of appetite
- weight loss
- frequent urination
- difficulty controlling urination
- muscle cramps
- joint pain, swelling, or stiffness
- pain
- excessive tiredness
- difficulty falling asleep or staying asleep
- headache
- dizziness
- nervousness
- depression
- confusion
- changes in behavior or mood
- hallucinations (seeing things or hearing voices that do not exist)
- abnormal dreams
- red, scaling, itchy skin
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
- fainting
- slow heartbeat
- chest pain
- new or worsening breathing problems
- new or worsening stomach pain or heartburn
- black or tarry stools
- red blood in stools
- bloody vomit
- vomit that looks like coffee grounds
- difficulty urinating or pain when urinating
- lower back pain
- fever
- seizures
- discoloration or bruising of the skin
Donepezil may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include the following:
- nausea
- vomiting
- drooling
- sweating
- slow heartbeat
- difficulty breathing
- muscle weakness
- fainting
- seizures
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS® Patient Medication Information™. © Copyright, 2024. The American Society of Health-System Pharmacists®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
Selected Revisions: December 15, 2017.
This information does not replace the advice of a doctor. Ignite Healthwise, LLC, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.